The last proposed mechanism of RBC vasodilation within the presence of nitrite may be the reduction of nitrite to NO by Hb. Brooks initially researched the nitrite Hb conversation in 1937 which do the job was later extended by Doyle in 1981 (Brooks, 1937; Doyle et al., 1981). Nitrite reacts with deoxygenated Hb to type metHb and NO (Brooks, 1937; D